The question is "what do you want out of it?"

As stated you can find systems with great POT and they are all low number of bets. The otherside of this is a small POT but volume. If you are after a greater profit and better security then you are better with the latter. I would always choose to have 10% of a million over 50% of a thousand.

Alternatively you have to ask how did the greater POT system get its profit. If it was from longshots, how are you going to replicate the returns? To go down this path you need many systems with similar POTs and then you need to automate the selection process and have a method of ensuring every selection is bet. Sounds simple. Get a dozen systems with 50%+ POT, generate the selections via BetSelector or the like, then back them and sit back with a stubby and watch the profits come in. The reality is that you will need deep pockets and in the week that you go away with the missus all the longshots come in. The smaller the number of bets the more unlikely it will replicate itself.