It depends. Last year I backed St Kilda pre-season at $8. Then I backed Brisbane and Port Adelaide mid season at $3.85 & $7.50. Come Grand Final day I was sitting on a minimum of 87.5% profit, no matter the result of the game. Wouldn't have done as well if I had waited till Rd 22. The one bet that I reckon you really should wait until Rd 22 for is the Brownlow.